Hepatic Regeneration-Revisiting the Myth of Prometheus.
نویسنده
چکیده
Myriad signals such as growth factors, cytokines, growth inhibitors, hormones, ions, extracellular matrix, and the resident hepatic cells are involved in the regulation of hepatic regeneration. These regulatory factors ultimately mediate changes in gene expression, a critical step in this well-orchestrated restorative process.
منابع مشابه
The myth of Prometheus and the liver.
Introduction A recent viewing ofthe painting, Prometheus Bound by Peter Paul Rubens (Boston Museum of Fine Arts Exhibition, 1993), brings to mind the role ofthe liver in the myth of Prometheus. Rubens' powerful scene (completed 1618) depicts an enchained Prometheus writhing in the foreground with an eagle pecking at the exposed liver (Figure 1)1. In the legend, the eagle's meal is repeated ever...
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367 The proliferative capacity of the liver is vividly captured in the Greek myth of Prometheus. Having stolen fire and tricked Zeus, Prometheus was chained to a rock and sentenced to have his liver eaten each day by an eagle. Because his liver re-grew nightly, he could endure the same punishment endlessly. Although the myth exaggerates the rate at which normal liver mass can be reconstituted, ...
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In this review, we present examples of the contribution of transgenic mice to our knowledge concerning the type of cells that are able to repopulate a damaged liver and information on the factors and mechanisms involved in postnatal liver growth and regeneration. The transgenic technology offers the opportunity to evaluate the physiological consequences of perturbating expression of a given gen...
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The first mention of hepatic regeneration can be traced to the Greek legend of Prometheus, which was developed centuries before the birth of Christ (Esiodo, B.c.). However, it was only toward the end of the 19th century that the first experimental observations performed on laboratory animals were reported demonstrating complete restoration of hepatic mass following either a partial hepatectomy ...
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The liver has a peculiar and fascinating ability: it is able to regenerate itself after loss of parenchyma for surgical resection or injuries caused by drugs, toxins or acute viral diseases. The ancient myth of Prometheus highlighted this capability: the Titan Prometheus was bound for ever to a rock as punishment by Zeus for his theft of the fire; each day a great eagle ate his liver and each n...
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عنوان ژورنال:
- News in physiological sciences : an international journal of physiology produced jointly by the International Union of Physiological Sciences and the American Physiological Society
دوره 14 شماره
صفحات -
تاریخ انتشار 1999